Andrew G. York

Our lab develops new microscopy techniques.

We work at Calico Labs

We're hiring!

We follow a "do it yourself" approach to scientific publishing. Some work is quite polished, some is still rough, but hopefully all of it is useful to someone:

• From cameras to confocal to cytometry: measuring tumbling rates is a general way to reveal protein binding
  • Public discussion: [1]
• Magnetic control of GFP-like fluorescent proteins
  • Public discussion: [1]
• Any immersion remote refocus (AIRR) microscopy
  • Public discussion: [1]
• Extending fluorescence anisotropy to large complexes using reversibly switchable proteins (note that this is a "traditional" publication from the Testa lab, that we contributed to.)
  • Relevant later work: [1] [2]
  • Public discussion: [1]
• mScarlet fluorescence lifetime reports lysosomal pH quantitatively
  • Public discussion: [1]
• Relaxation sensors
  • Public discussion: [1]
• Split-wrmScarlet and split-sfGFP: tools for faster, easier fluorescent labeling of endogenous proteins in Caenorhabditis elegans
  • Other formats: [1] [2]
• High NA single objective light sheet
  • Relevant later work: [1, 2] [3, 4] [5, 6]
  • Public discussions: [1] [2] [3] [4] [5] [6] [7]
• Stimulated emission imaging
  • Relevant later work: [1, 2] [3]
  • Public discussions: [1] [2]
• What is the signal-to-noise ratio of phase-contrast imaging? Can it be infinite?
  • Relevant later work: [1]
  • Public discussions: [1] [2] [3]
• Remote refocus enables class-leading spatiotemporal resolution in 4D optical microscopy
  • Public discussion: [1]
• Line-rescanned STED microscopy is gentler and faster than point-descanned STED microscopy
  • Relevant work: [1]

Here's a template, if you're interested in trying this approach yourself:

• A template for writing scientific papers

We use a similar approach for sharing scientific code:

• Simple demo of structured illumination microscopy image fusion via Richardson-Lucy deconvolution
• Periodic plus smooth image decomposition, as described by Moisan

And, in the spirit of open science, we've shared a few works in progress:

• Photoswitching noise distorts all fluorescent images
• Lens-free scanning
  • Public discussion: [1] [2] [3] [4]